PPFIA1 (PTPRF interacting protein alpha 1) encodes liprin-α1, a scaffold protein that plays complex roles in cell adhesion, migration, and oncogenic signaling. The protein localizes to focal adhesions and functions in α5β1 integrin recycling, coordinating fibronectin fibrillogenesis and vascular morphogenesis 1. PPFIA1 contains MAH and three SAM domains that facilitate protein-protein interactions and oligomerization 2. Functionally, PPFIA1 demonstrates context-dependent roles in cancer: it acts as an invasion suppressor in head and neck squamous cell carcinoma (HNSCC), where knockdown increases cellular invasiveness 3, yet promotes migration and invasion in esophageal squamous cell carcinoma 4. The protein regulates oncogenic MAPK signaling by counteracting ERK activity, with depletion leading to increased p-ERK1/2 levels and enhanced RAS membrane localization 5. PPFIA1 is frequently amplified in the 11q13 region across multiple cancer types 23. High PPFIA1 expression correlates with poor prognosis in esophageal cancer and colorectal cancer when combined with ALG3 overexpression 46. These findings establish PPFIA1 as a crucial regulator of cell-matrix interactions with tumor-type-specific oncogenic functions.