PPFIA2 encodes Liprin-α2, a scaffolding protein that plays critical roles in synaptic organization and cellular adhesion. The protein functions as a synaptic scaffold in dendritic spines, serving as an immobile postsynaptic post that recruits KIF1A-driven dense core vesicles to dendritic spines 1. PPFIA2 alters PTPRF cellular localization and induces PTPRF clustering, potentially regulating focal adhesion disassembly and localizing receptor-like tyrosine phosphatases at specific plasma membrane sites 1. The protein contains multiple functional domains including PFIH domains and three SAM domains, with regions spanning SAM1-SAM3 serving as binding domains for LAR subfamily protein tyrosine phosphatases 2. Clinically, de novo variants in PPFIA2 are associated with neurodevelopmental disorders, supported by gene constraint metrics and identification in multiple affected individuals 3. The gene shows altered expression in various pathological conditions, including increased expression in colorectal cancer where PPFIA4 serves as a prognostic marker 4, elevated expression in cannabis users correlating with decreased neuropsychological function 5, and downregulation associated with Alzheimer's disease risk in aging men 6. Additionally, PPFIA2 has been implicated as a candidate gene for high-grade myopia within the MYP3 locus 7.