PPP2R2C encodes the B-gamma regulatory subunit of protein phosphatase 2A (PP2A), which modulates substrate selectivity and catalytic activity of the phosphatase complex 1. This brain-abundant subunit shows unique expression patterns, with high levels in brain tissue and nearly undetectable expression in other tissues 1. Functionally, PPP2R2C plays crucial roles in multiple cellular processes. In embryonic stem cells, it participates in a PP2A complex that reduces Erk1/2 activity, contributing to the regulation of pluripotency through Netrin-1 signaling pathways 2. The protein also regulates tau dephosphorylation and PP2A activity, with expression being downregulated in Alzheimer's disease mouse models, suggesting involvement in neurodegeneration 3. Clinically, PPP2R2C disruption is associated with autosomal dominant intellectual disability, epilepsy, and behavioral problems 4, while genetic variants are linked to ADHD and personality traits 5. In cancer contexts, PPP2R2C functions as a tumor suppressor, being downregulated in gliomas, nasopharyngeal carcinoma, and ovarian cancers 678. When overexpressed, it inhibits cancer cell proliferation through mTOR pathway suppression by enhancing PP2A-S6K complex formation 6.