1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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3PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence
regulation of double-strand break repairprotein phosphatase activator activityDNA damage responsenucleoplasm
PPP4R3C (protein phosphatase 4 regulatory subunit 3C) is a regulatory subunit of the protein phosphatase 4 complex involved in DNA damage response and double-strand break repair. Based on limited published evidence, PPP4R3C localizes to the nucleoplasm and exhibits protein phosphatase activator activity. A single transcriptomic study 1 identified PPP4R3C as differentially expressed in fetal testicular tissue under nutrient restriction conditions, though functional characterization in this context remains unexplored. Direct molecular mechanisms and physiological roles require further investigation.
1
PPP4R3C showed increased expression in nutrient-restricted fetal testicular tissue compared with melatonin-supplemented nutrient-restricted conditions
PMID: 41514165⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.