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1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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PPP4R3C
protein phosphatase 4 regulatory subunit 3C
Chromosome X · Xp21.3
NCBI Gene: 139420
3PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence
regulation of double-strand break repairprotein phosphatase activator activityDNA damage responsenucleoplasm
✦AI Summary

PPP4R3C (protein phosphatase 4 regulatory subunit 3C) is a regulatory subunit of the protein phosphatase 4 complex involved in DNA damage response and double-strand break repair. Based on limited published evidence, PPP4R3C localizes to the nucleoplasm and exhibits protein phosphatase activator activity. A single transcriptomic study 1 identified PPP4R3C as differentially expressed in fetal testicular tissue under nutrient restriction conditions, though functional characterization in this context remains unexplored. Direct molecular mechanisms and physiological roles require further investigation.

Sources cited
1
PPP4R3C showed increased expression in nutrient-restricted fetal testicular tissue compared with melatonin-supplemented nutrient-restricted conditions
PMID: 41514165
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
PPP4R3AProtein interaction99%PPP4R3BProtein interaction99%PTPAProtein interaction99%PPP3CAProtein interaction94%CRTC2Protein interaction92%PPP2CAProtein interaction85%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
PPP4R3CPPP4R3APPP4R3BPTPAPPP3CACRTC2PPP2CA
PROTEIN STRUCTURE
?
No structure data available
Structures require a reviewed Swiss-Prot entry.
RankingsWhere PPP4R3C stands among ~20K protein-coding genes
  • #19,006of 20,598
    Most Researched3
Genes detectedPPP4R3C
Sources retrieved1 papers
Response time—
📄 Sources
1
1
Integrated fetal testicular transcriptomic and epigenomic profiles during maternal nutrient restriction with dietary melatonin intervention.
PMID: 41514165
J Anim Sci · 2026
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