Based on limited published evidence, PRAMEF1 functions as a component of the Cul2-RING ubiquitin ligase complex involved in proteasome-mediated ubiquitin-dependent protein catabolism, localized to the cytoplasm with ubiquitin-like ligase-substrate adaptor activity. PRAMEF1 is significantly overexpressed in androgenotes compared to biparental embryos 1, suggesting a role in paternal genome contribution during early zygotic genome activation in embryonic development. However, its specific molecular targets and precise mechanisms remain undefined.