1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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6PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingubiquitin-like ligase-substrate adaptor activityCul2-RING ubiquitin ligase complexproteasome-mediated ubiquitin-dependent protein catabolic process
Based on limited published evidence, PRAMEF10 is a PRAME family member predicted to function in protein ubiquitination and degradation. GO annotations indicate involvement in the Cul2-RING ubiquitin ligase complex and proteasome-mediated ubiquitin-dependent protein catabolism, with ubiquitin-like ligase-substrate adaptor activity in the cytoplasm. A genomic variant screening study flagged PRAMEF10 as a potential candidate gene in autism spectrum disorder 1, though its specific role in neurodevelopment remains unclear.
1
PRAMEF10 identified as a novel candidate gene potentially involved in autism spectrum disorder in a Russian cohort using whole-exome sequencing
PMID: 35627305⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.