PRLH (prolactin-releasing hormone) is a neuropeptide that functions primarily in energy homeostasis rather than prolactin regulation. The peptide signals through the G protein-coupled receptor GPR10 to regulate feeding behavior and body weight 1. PRLH-expressing neurons in the nucleus tractus solitarius (NTS) represent a critical neural circuit component for long-term energy balance control. Activation of NTS Prlh neurons suppresses food intake, overcomes orexigenic hypothalamic signals (such as those from AgRP neurons), and ameliorates obesity in both high-fat diet-challenged and genetically obese mice 2. This appetite-suppressive function operates independently of prolactin secretion pathways 3. Recent evidence demonstrates that NTS Calcr/Prlh neurons show sustained transcriptional changes in response to anti-obesity amylin analogs in rodent models, with increased Prlh expression correlating with long-term weight loss 4. PRLH also participates in nicotine-mediated feeding regulation 5. While initially identified as a prolactin-releasing factor, PRLH's physiological role centers on appetite suppression and metabolic homeostasis, making it a potential therapeutic target for obesity treatment.