QRFP (pyroglutamylated RFamide peptide) is a neuropeptide that functions as a key regulator of energy homeostasis and feeding behavior through its cognate receptor GPR103. QRFP stimulates food intake, particularly high-fat foods, when administered centrally in rodents 12. The peptide is expressed primarily in hypothalamic nuclei involved in feeding control, with expression levels increased in obese animals and upregulated by high-fat diet consumption 31. Beyond feeding regulation, QRFP demonstrates broader metabolic functions including glucose homeostasis regulation, acting as an incretin that reduces glucose-induced hyperglycemia and increases insulin sensitivity 3. The peptide also regulates adrenal steroidogenesis, inducing aldosterone and cortisol secretion through PKC and T-type calcium channel-mediated pathways in human adrenocortical cells 4. QRFP-expressing neurons in the preoptic hypothalamus can induce hibernation-like hypothermic states when stimulated, suggesting roles in thermoregulation and cardiovascular function 5. The neuropeptide system shows sexual dimorphism, with expression varying across the estrous cycle in females 2. QRFP represents a multifunctional neuropeptide system central to energy balance, metabolic regulation, and stress-related physiological responses 67.