QRFPR (pyroglutamylated RFamide peptide receptor) is a G protein-coupled receptor that serves as the cognate receptor for the orexigenic neuropeptide 26RFa/QRFP 1. The receptor mediates diverse physiological functions including food intake regulation, energy homeostasis, bone formation, pituitary hormone secretion, and blood pressure control 1. QRFPR signaling involves G protein-mediated modulation of adenylate cyclase activity and intracellular calcium mobilization 2. The receptor also activates the PI3K-AKT-mTOR signaling pathway, which appears important for neurodevelopmental processes 2. N-glycosylation at specific asparagine residues (N19 and N106) is essential for ligand binding and receptor activation, though not required for cell surface expression 3. Functionally significant variants in QRFPR have been identified in patients with intellectual disability and feeding difficulties, demonstrating impaired calcium mobilization and PI3K-AKT-mTOR signaling 2. Additionally, QRFPR variants have been associated with preeclampsia susceptibility 4 and autoantibodies against QRFPR have been detected in type 1 diabetes patients 5. The receptor shows evolutionary complexity with multiple paralogs in early vertebrates that were subsequently lost in mammals 6.