PTPRF (protein tyrosine phosphatase receptor type F) is a receptor-type protein tyrosine phosphatase with dual catalytic domains, where the first domain possesses enzymatic activity while the second modulates substrate specificity 1. The protein functions as a transmembrane signaling molecule involved in cell adhesion and cell-cell interactions, with roles in nervous system development and signal transduction 1. Mechanistically, PTPRF regulates phosphotyrosine levels through multiple pathways. It suppresses Wnt/β-catenin signaling in colorectal cancer by dephosphorylating LRP6 via clathrin-mediated endocytosis 2. PTPRF also negatively regulates EGFR phosphorylation in breast cancer, with its downregulation by miR-24 promoting tumor invasion and metastasis 3. In hepatocellular carcinoma, miR-647-mediated PTPRF inhibition activates ERK signaling, enhancing proliferation and invasion 4. Disease relevance encompasses both developmental and oncological contexts. PTPRF disruption causes syndromic amastia (breast aplasia/hypoplasia), implicating it in human mammary gland development 5. PTPRF variants are putatively causal for ADHD in fetal and adult cortical tissues 6 and are associated with reproductive-related disorders 7. Clinically, PTPRF functions as a tumor suppressor; PPARγ activation upregulates PTPRF to inhibit breast cancer progression, suggesting therapeutic potential through PTPRF restoration 8.