Based on limited published evidence, PTPRZ2 is a protein tyrosine phosphatase receptor type Z2 located on chromosome 1, a region frequently deleted in human malignancies. The gene displays brain-specific expression with two transcripts of 7.9 and 6.5 kb 1. As a tyrosine phosphatase family member mapping to a chr1 region prone to deletions in human cancers, PTPRZ2 represents a potential candidate tumor suppressor gene 1. Further functional characterization is needed to establish its biochemical activity and role in cellular regulation.