RAB11FIP1 is a Rab11 effector protein primarily involved in endosomal recycling and membrane trafficking. It functions as a scaffolding protein that maintains Rab35 localization at the intercellular bridge during cytokinesis, facilitating actin removal and enabling cell division 1. RAB11FIP1 works with Rab11a to promote exosomal Wnt10a secretion and trafficking to the plasma membrane, supporting osteogenic differentiation of bone mesenchymal stem cells 2. The protein also plays roles in phagocytosis and intracellular pathogen trafficking, with upregulation associated with inhibition of Mycobacterium tuberculosis growth in human monocytes 3. In cancer biology, RAB11FIP1 acts as an epithelial-mesenchymal transition (EMT) driver. MicroRNA-93 downregulates RAB11FIP1 in cervical cancer to promote proliferation and suppress apoptosis 4, while circRTN4 stabilizes RAB11FIP1 protein to promote EMT and metastasis in pancreatic cancer 5. Beyond cancer, RAB11FIP1 is implicated in developmental disease susceptibility. Genetic studies identified RAB11FIP1 as a candidate gene in epithelial and pharyngeal arch cell types relevant to non-syndromic orofacial clefting 6. Differential expression of RAB11FIP1-derived circRNAs was also associated with recurrent pregnancy loss, particularly in decidual tissue 7.