SYNGR2 (synaptogyrin 2) is a membrane protein encoded on chromosome 17 telomeric region 1 that functions in regulating membrane trafficking in non-neuronal cells 2. The protein contains four conserved transmembrane domains conferring an M-shaped topology 1, and is expressed at high levels in most tissues except the brain 1. SYNGR2 plays a role in synaptic vesicle membrane organization and regulated exocytosis through its involvement in protein binding and extracellular exosome pathways. Mechanistically, SYNGR2 may participate in cytoplasmic inclusion body assembly required for SFTS phlebovirus replication during microbial infection. Clinically, SYNGR2 has emerged as a significant cancer biomarker. High SYNGR2 expression is associated with reduced overall survival, disease-specific survival, and disease-free interval across multiple cancer types 3. In hepatocellular carcinoma and esophageal squamous cell carcinoma, SYNGR2 expression correlates with poor prognosis, higher tumor stage, and altered immune infiltration patterns 32. SYNGR2 was identified as an upregulated protein in medulloblastoma's SHH subgroup 4 and inclusion in multi-gene diagnostic models improves preoperative differentiation of malignant from benign thyroid nodules 56, achieving 88.8% predictive accuracy.