SYNGR1 (synaptogyrin 1) is a transmembrane protein localized to neurotransmitter-containing vesicles that plays critical roles in synaptic function and regulation of exocytosis 1. The gene regulates short-term and long-term synaptic plasticity and modulates synaptophysin localization into synaptic-like microvesicles, contributing to vesicle formation and maturation. SYNGR1 expression is significantly reduced in glioblastoma; overexpression of SYNGR1 inhibits GBM cell proliferation, invasion, and adhesion by suppressing intracellular FGF1-mediated lipid droplet accumulation and cytoskeleton remodeling 2. Genetically, SYNGR1 variants are associated with psychiatric disorders. Multiple polymorphisms show association with schizophrenia susceptibility in Italian and Indian populations, with some rare variants potentially affecting gene expression and protein function 1. The gene also demonstrates association with bipolar disorder in southern Indian populations 3. Beyond neuropsychiatry, SYNGR1 has been identified as a susceptibility locus for Sjögren's disease in genome-wide association studies 4. Additionally, pollution-induced alterations in SYNGR1 expression, mediated through DNA methylation changes, are associated with increased risk of gastrointestinal diseases including gastric ulcer and ulcerative colitis 5. SYNGR1 represents a potential causal methylation-mRNA regulation chain in rheumatoid arthritis pathogenesis 6, and genetic variants near SYNGR1 associate with coagulation factor VIII and von Willebrand factor plasma levels, relevant to thrombotic disease risk 7.