SYNPR (synaptoporin) is an intrinsic membrane protein of small synaptic vesicles that functions as a probable vesicular channel protein 1. While its primary role involves synaptic vesicle structure and function, genome-wide association studies have identified SYNPR variants as significant genetic risk factors for multiple diseases. A meta-analysis of 1,622 Chinese AIH type 1 patients identified a SYNPR variant (rs6809477) exceeding genome-wide significance (OR=1.25, p=5.48×10⁻⁹), suggesting neuro-immune interactions contribute to autoimmune hepatitis pathogenesis 2. SYNPR variants also associate with gestational diabetes mellitus in Chinese populations, with pathway analysis indicating involvement in glycometabolism regulation 3. In cancer contexts, SYNPR appears significantly downregulated in glioblastoma tissues and cell lines, identifying it as a potential prognostic molecular marker 4. Additionally, SYNPR represents a dorsal horn pain-modulating gene linked to the BDNF/neuropathic pain pathway in chr3 pancreatitis, where genetic variants correlate with constant-severe pain experiences 5. The gene's disease associations suggest SYNPR function extends beyond synaptic vesicle biology to influence immune regulation, glucose metabolism, neural development, and pain processing, highlighting its importance as a cross-system genetic risk factor.