RAB11FIP2 is a Rab11 effector protein that regulates vesicular transport from the endosomal recycling compartment to the plasma membrane. It binds preferentially to phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid, functioning in insulin granule exocytosis, receptor-mediated endocytosis, and recycling endosome trafficking 1. RAB11FIP2 plays critical roles in maintaining endothelial barrier integrity; its downregulation by exosomal miR-142-3p during cardiac allograft rejection increases vascular permeability and contributes to transplant rejection 1. The protein is also involved in cell polarity establishment and phagocytosis through actin dynamics regulation 2. Clinically, RAB11FIP2 downregulation occurs in breast cancer-derived extracellular vesicles breaching the blood-brain barrier, facilitating brain metastasis by altering endothelial cell dynamics 3. Genome-wide association studies identified RAB11FIP2 variants associated with skin-related traits in Japanese populations 4 and male-specific inguinal hernia susceptibility 5. In cancer contexts, RAB11FIP2 expression correlates positively with TRIM13 in breast cancer prognosis 6, and it serves as a key target gene of miR-16-5p in gastric cancer TLR signaling 7. Neurodevelopmental disorders have been associated with rare RAB11FIP2 truncation variants 8.