RAB29 is a small GTPase that regulates intracellular membrane trafficking by cycling between inactive GDP-bound and active GTP-bound states to recruit effector proteins 1. RAB29 maintains endosome-trans-Golgi network integrity and works with LRRK2 in retrograde trafficking pathways to recycle proteins like mannose 6-phosphate receptor between lysosomes and the Golgi apparatus 1. Critically, RAB29 recruits LRRK2 to the Golgi complex and stimulates its kinase activity through an asymmetrical tetrameric assembly mechanism, where Rab29 induces LRRK2 oligomerization with kinase-active central and kinase-inactive peripheral protomers 2. RAB29 also stimulates LRRK2-mediated phosphorylation of RAB10 2. RAB29 variants, particularly the rs823144 C allele, are associated with reduced Parkinson's disease (PD) risk and altered lysosomal enzyme activity and sphingolipid profiles 3. Genome-wide association studies identify RAB29 as a PD risk locus, with genetic evidence supporting its role in endosomal sorting dysfunction central to PD pathogenesis 45. Additionally, RAB29 may facilitate typhoid toxin transport during Salmonella typhi infection 6.