RAMP2 is a receptor activity-modifying protein that functions as a critical accessory component for G-protein coupled receptors, particularly the calcitonin receptor-like receptor (CALCRL) and calcitonin receptor (CALCR) 1. RAMP2 is essential for trafficking CALCRL to the plasma membrane and forms functional receptor complexes with CALCRL for adrenomedullin (ADM) signaling and with CALCR for calcitonin and amylin signaling 12. The ADM-RAMP2 system maintains vascular integrity and endothelial homeostasis across developmental and adult stages 3. RAMP2 regulates amylin receptor signaling through dynamic subunit association modulated by peptide agonists, affecting downstream cAMP signaling 4. Clinically, the ADM-RAMP2 system demonstrates vasoprotective functions, reducing neointimal hyperplasia and vascular inflammation after injury, with therapeutic potential for atherosclerosis and restenosis prevention 5. In liver regeneration, hepatocyte RAMP2 upregulation promotes sinusoidal endothelial cell proliferation and vascular reconstitution via altered PEDF/VEGFA expression, with PEDF/VEGFA ratios serving as biomarkers for post-hepatectomy liver failure risk 6. Additionally, the AM-RAMP2 system suppresses inflammatory responses in uveitis by promoting regulatory T cells and M2 macrophages, suggesting therapeutic applications in autoimmune diseases 7.