RAMP2 is a receptor accessory protein that modulates G-protein coupled receptor signaling, primarily by enabling ligand recognition and plasma membrane localization of receptor complexes. It functions as a co-receptor with calcitonin receptor-like receptor (CALCRL) to form the adrenomedullin receptor and with calcitonin receptor (CALCR) to form receptors for calcitonin and amylin. The RAMP2-containing receptor complexes activate adenylate cyclase signaling and control vascular homeostasis across multiple tissues. Ramp2 expression is dynamically regulated in disease contexts. In post-hepatectomy liver failure, upregulation of Ramp2 in hepatocytes promotes vascular reconstitution through increased endothelial proliferation and sinusoid formation 1. The adrenomedullin-RAMP2 system maintains vascular integrity in endothelial cells and protects against neointimal hyperplasia after vascular injury 23. In experimental autoimmune uveitis, RAMP2-dependent signaling suppresses inflammatory cell infiltration and promotes regulatory T-cell and M2 macrophage responses 4. The system also supports retinal vascular development and limits pathological neovascularization in oxygen-induced retinopathy 5. Amylin receptor signaling through RAMP2-CTR heterodimers is a target for diabetes and obesity pharmacotherapy. Pramlintide (amylin analogue) is approved for diabetes management, and RAMP2 heterodimer stability and subunit dynamics modulate the extent of downstream cAMP signaling 6. Recent evidence suggests the AM-RAMP2 system may influence Alzheimer's disease pathophysiology 7, although this requires further investigation.