RAMP3 (receptor activity modifying protein 3) is an accessory protein that modulates G-protein coupled receptor function by forming heteromeric complexes with calcitonin receptors and related proteins. RAMP3 acts as a required co-factor for plasma membrane trafficking of receptors including calcitonin receptor-like receptor (CALCRL) and G-protein coupled estrogen receptor 1 (GPER1) 12. As a structural component, RAMP3 combines with CALCRL to form the adrenomedullin 2 (ADM2) receptor complex 34 and with calcitonin receptor (CTR) to constitute the amylin receptor 3 (AMY3R), where it stabilizes subunit interactions and regulates agonist-dependent signaling dynamics 56. RAMP3-mediated signaling activates downstream cAMP and calcium-dependent pathways 57. Clinically, RAMP3 variants are associated with age-related changes in body composition and increased fracture risk in elderly women 89. The ADM2-RAMP3 pathway promotes tissue-protective responses in intestinal innate lymphoid cells, with altered expression observed in inflammatory bowel disease patients 3. Additionally, RAMP3 participates in cardiovascular regulation through cerebellar adrenomedullinergic signaling, with dysregulation contributing to hypertension 7.