RANBP6 is a nuclear transport receptor involved in protein import through the nuclear pore complex 1. It functions as a member of the importin β family and mediates nuclear translocation of cargo proteins, including STAT3 1. RANBP6 plays a regulatory role in EGFR signaling by facilitating STAT3 nuclear import, which then binds the EGFR promoter to suppress EGFR transcription, thereby providing negative feedback regulation of EGFR pathway activity 1. Loss or deletion of RANBP6 impairs STAT3 nuclear translocation, leading to EGFR derepression and increased proliferative signaling 1. Functionally, RANBP6 is implicated in multiple disease contexts: focal deletions of the RANBP6 locus on chromosome 9 occur in glioblastoma, and RanBP6 silencing promotes glioma growth in vivo 1. RANBP6 was identified as one of 24 key genes important in 9p deletion syndrome, affecting the majority of individuals with this chr9 disorder 23. Additionally, RANBP6 was identified as a pyroptosis-related gene with diagnostic potential in heart failure pathogenesis 4. The gene shows copy number variation in lymphoid malignancies within the 9p24.1 amplified region 5. These findings establish RANBP6 as a tumor suppressor with critical roles in nuclear transport regulation and cancer prevention.