HomeAboutRankingsData Sources
© 2026 GeneE
🧬
GeneE
2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
BRD10
bromodomain containing 10
Chromosome 9 · 9p24.1
NCBI Gene: 158358Ensembl: ENSG00000183354.12HGNC: HGNC:23378UniProt: Q5HYC2
17PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Swiss-Prot Reviewed
nucleusAbnormality of the skeletal systemasthmabenign neoplasmchronic rhinosinusitis with nasal polyps
✦AI Summary

Based on limited published evidence, BRD10 is a bromodomain-containing protein located on chromosome 9. The primary functional information derives from its identification as one of 24 genes prioritized in comprehensive genomic analyses of 9p deletion syndrome 12. BRD10 was selected based on statistical assessment of human genomic variation and spatial transcriptomics of embryonic mouse tissue, indicating relevance to craniofacial and brain development. The gene is implicated in the phenotypic manifestations affecting the majority (83%) of individuals with 9p deletion syndrome, though specific molecular functions remain to be elucidated.

Sources cited
1
BRD10 identified as one of 24 important genes for majority of 9p deletion syndrome cases through WGS analysis and spatial transcriptomics
PMID: 40196253
2
BRD10 prioritized as important gene for 9p deletion syndrome through statistical genomic assessment and spatial transcriptomics of embryonic mouse tissue
PMID: 41137173
⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Abnormality of the skeletal systemOpen Targets
0.32Weak
asthmaOpen Targets
0.29Weak
benign neoplasmOpen Targets
0.27Weak
chronic rhinosinusitis with nasal polypsOpen Targets
0.26Weak
WheezingOpen Targets
0.24Weak
multiple sclerosisOpen Targets
0.24Weak
crush injuryOpen Targets
0.22Weak
adult onset asthmaOpen Targets
0.16Weak
childhood onset asthmaOpen Targets
0.15Weak
allergic rhinitisOpen Targets
0.14Weak
B-cell acute lymphoblastic leukemiaOpen Targets
0.13Weak
chronic rhinosinusitisOpen Targets
0.13Weak
respiratory system diseaseOpen Targets
0.13Weak
allergic diseaseOpen Targets
0.13Weak
deep vein thrombosisOpen Targets
0.11Weak
respiratory tract infectious disorderOpen Targets
0.10Weak
protozoa infectious diseaseOpen Targets
0.10Suggestive
lower respiratory tract diseaseOpen Targets
0.09Suggestive
Abnormal thrombosisOpen Targets
0.09Suggestive
SplenomegalyOpen Targets
0.09Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
DMRT2Co-mentioned in literature100%RCL1Co-mentioned in literature100%RIC1Co-mentioned in literature100%PUM3Co-mentioned in literature100%RANBP6Co-mentioned in literature100%AK3Co-mentioned in literature100%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
95%
Ovary
89%
Heart
83%
Lung
56%
Liver
42%
Gene Interaction Network
Click a node to explore
BRD10DMRT2RCL1RIC1PUM3RANBP6AK3
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q5HYC2
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.56Moderately Constrained
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.46 [0.37–0.56]
RankingsWhere BRD10 stands among ~20K protein-coding genes
  • #14,927of 20,598
    Most Researched17
  • #3,661of 17,882
    Most Constrained (LOEUF)0.56 · top quartile
Genes detectedBRD10
Sources retrieved2 papers
Response time—
📄 Sources
2
1
Whole-Genome Sequencing Reveals Individual and Cohort Level Insights into Chromosome 9p Syndromes.
PMID: 40196253
medRxiv · 2025
1.00
2
Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes.
PMID: 41137173
Genome Med · 2025
0.50