RAPH1 (Ras association and pleckstrin homology domains 1) encodes lamellipodin (Lpd), a protein that mediates localized membrane signals and regulates cytoskeletal dynamics 1. The protein modulates actin cytoskeleton assembly through binding to Ena/VASP proteins and controls cellular motility and lamelipodial protrusion 1. RAPH1 negatively regulates cell adhesion and is involved in re-epithelialization processes, as evidenced by its role as a target of miR-203 during wound healing 2. The gene shows significant disease relevance in cancer, particularly breast cancer, where high RAPH1 expression correlates with aggressive tumor phenotypes including higher grade, high proliferation index, and triple-negative status 3. A nuclear isoform (RAPH1-i3) interacts with FOXQ1 transcription factor to promote breast cancer aggressiveness and radioresistance through STAT3 signaling activation 4. Clinically, RAPH1 overexpression serves as an independent predictor of poor prognosis and shorter survival in breast cancer patients 3. The gene also shows copy number alterations in various cancers 1 and has been implicated in metabolic regulation through its association with adiposity-related DNA methylation patterns 5. Additionally, RAPH1 variants are associated with butyrylcholinesterase activity regulation 6.