RASD1 (Ras-related dexamethasone induced 1) encodes a small GTPase with diverse cellular functions across multiple pathological contexts. As a member of the Ras superfamily, RASD1 functions as a tumor suppressor, showing significant downregulation in several cancer types and correlating with favorable prognosis when highly expressed 1. The protein regulates apoptosis through the mitochondrial pathway, as demonstrated by its upregulation during formononetin-induced apoptosis in prostate cancer cells alongside increased Bax and decreased Bcl-2 expression 2. RASD1 plays a critical role in metabolic regulation, particularly in lipid metabolism where it promotes lipogenesis through the PI3K/AKT/mTOR pathway in metabolic dysfunction-associated steatotic liver disease (MASLD) 3. The protein also contributes to cardiovascular pathology, with reduced expression associated with impaired autophagy and increased cardiac hypertrophy risk in females 4. Additionally, RASD1 is involved in neuropsychiatric disorders, with rare variants potentially contributing to schizophrenia pathogenesis 5. The protein appears to modulate immune signaling, as high expression correlates with increased CD4+ T cell and dendritic cell infiltration in cancer 1. RASD1 also participates in inflammatory processes, being expressed in lipofibroblasts during thyroid-associated ophthalmopathy 6.