RASL10B (RAS like family 10 member B) is a small monomeric GTPase belonging to the Ras protein superfamily 1. The gene encodes a 203 amino acid protein (~23.2 kDa) distributed in the cytoplasm and is extensively expressed across human tissues 1. According to functional annotations, RASL10B may facilitate atrial natriuretic peptide release by cardiomyocytes and regulate systemic arterial blood pressure through positive regulation of peptide hormone secretion. RASL10B exhibits tumor suppressor potential, as mRNA levels are consistently downregulated in human breast cancer cell lines 1. In colorectal cancer, RASL10B was identified as part of a succinylation-related prognostic model where high-risk patients showed significantly shorter overall survival 2. Similarly, it was incorporated into a three-gene prognostic signature for prostate cancer risk stratification 3. RASL10B appeared in a right-sided colon cancer-specific prognostic model alongside EREG, ERFE, and GFI1 4. In hepatocellular carcinoma, RASL10B showed consistent differential expression in invasive cells, suggesting a role in tumor invasiveness 5. Additionally, RASL10B promoter methylation accumulated during the aberrant crypt foci-to-cancer progression in sessile serrated adenomas, indicating epigenetic silencing in colorectal tumorigenesis 6.