FGA (fibrinogen alpha chain) encodes one of three polypeptide chains (Aα, Bβ, γ) that assemble into the hexameric fibrinogen protein, a major component of the blood coagulation system 1. The FGA gene is located in a cluster with FGB and FGG genes on chromosome 4, and their coordinated expression is regulated by conserved hepatic enhancer elements, including a potent enhancer (PFE2) located between FGA and FGG that drives liver-specific expression 2. During coagulation, fibrinogen is cleaved by thrombin to form fibrin monomers that polymerize into blood clots. Fibrinogen synthesis is induced up to 3-fold during inflammatory responses, and abnormal levels are associated with bleeding, thrombotic disorders, and inflammatory diseases 1. While genetic variants in FGA, including the rs6050 polymorphism, have been studied for associations with ischemic stroke risk, meta-analysis has not demonstrated significant associations 3. Clinically, FGA expression has emerged as a prognostic biomarker in gastric cancer, where high expression correlates with poor survival outcomes 4. Additionally, FGA plays roles in muscle adaptation during exercise and colon cancer progression, with its expression modulated by compounds like glycerophosphoinositol 5.