RBM47 is a single-stranded RNA-binding protein that plays critical roles in multiple RNA processing mechanisms and cellular functions. The protein functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1, forming an mRNA editing complex that catalyzes cytidine to uridine editing in various mRNA molecules 1. RBM47 regulates alternative splicing by binding to (U)GCAUG consensus sequences in downstream intronic regions, controlling exon inclusion and exclusion 1. Additionally, RBM47 stabilizes mRNAs through 3'UTR binding and regulates expression of genes including interferon alpha/beta receptor and interleukin-10 1. In disease contexts, RBM47 demonstrates tumor suppressor functions across multiple cancer types. In colorectal cancer, RBM47 expression is decreased and associated with poor survival, with loss leading to increased proliferation and abnormal intestinal morphology 2. RBM47 overexpression in colorectal cancer cells reduces proliferation, increases apoptosis, and inhibits invasion through regulation of cell cycle and apoptosis-associated genes 3. In pancreatic cancer, RBM47 promotes tumor progression by upregulating PDIA6 through mRNA stabilization, enhancing cell proliferation and immune evasion 4. The protein is essential for vertebrate development, with loss causing perinatal lethality in mice and developmental defects in zebrafish 1.