RBMX2 is an X-linked RNA-binding protein involved in pre-mRNA splicing as a component of the activated spliceosome, particularly the minor spliceosome for U12-type intron splicing 1. The protein localizes to the nucleus and nucleoplasm where it participates in U2-type spliceosome assembly and catalytic steps of mRNA processing 2. Beyond its canonical splicing function, RBMX2 has emerged as a regulatory protein with broader cellular implications. It interacts with host and pathogen-derived proteins to modulate cellular processes: RBMX2 interacts with T. annulata-derived TA05575 protein, contributing to cellular transformation through altered transcription regulation 3. In mycobacterial infection contexts, RBMX2 suppresses cell adhesion and tight junctions while promoting pathogen invasion via p65 signaling, simultaneously driving epithelial-mesenchymal transition (EMT) through p65/MMP-9 pathway activation 4. Clinically, RBMX2 holds diagnostic and disease relevance across multiple conditions. RBMX2 transcript levels serve as a potential molecular marker to predict sperm presence in azoospermic men with maturation arrest, offering non-invasive diagnostic value 5. Structurally, an Alu element deletion in RBMX2 intron 3 segregates with bipolar disorder type I in an extended family, implicating this variant as a genetic contributor to psychiatric disease 6. Additionally, RBMX2 is identified as a candidate escape gene from X-chromosome X potentially contributing to intellectual disability in females 1.