SNRPF encodes a core component of small nuclear ribonucleoproteins (snRNPs) that functions in pre-mRNA splicing as part of the spliceosome machinery. The protein is a fundamental building block of U1, U2, U4, and U5 snRNPs and participates in both pre-catalytic spliceosome B complexes and activated spliceosome C complexes 1. SNRPF also functions in the minor spliceosome for U12-type intron splicing and as part of U7 snRNP for histone 3'-end processing 23. Beyond its core splicing function, SNRPF appears to have disease-relevant roles. In gliomas, SNRPF expression promotes cell migration and invasion, with UCH-L5 inhibiting these processes by downregulating SNRPF 4. The protein has been implicated in various pathological conditions, including tuberculosis infection where Mycobacterium tuberculosis targets SNRPF to disrupt host snRNP biogenesis 5, and in metabolic disorders where SNRPF genetic variants associate with type 2 diabetes through innate immune system regulation 6. SNRPF also shows altered expression in hepatocellular carcinoma via its pseudogene SNRPFP1 7 and has been identified as a hub gene in lung squamous cell carcinoma metastasis 8.