SNRPG (small nuclear ribonucleoprotein polypeptide G) functions as a core component of spliceosomal snRNPs (U1, U2, U4, U5), participating in pre-mRNA splicing as part of both precatalytic B and activated C spliceosomal complexes 12. Beyond major spliceosome function, SNRPG participates in U12-type intron splicing 3 and histone 3'-end processing as part of U7 snRNP 4. Beyond canonical splicing roles, SNRPG exhibits broader biological significance in disease pathogenesis. In glioblastoma, SNRPG downregulation induces cell cycle arrest and sensitizes cells to temozolomide through Myc and p53-dependent pathways, with elevated SNRPG expression conferring chemoresistance 5. In non-small cell lung cancer, 5-hydroxytryptamine promotes metastasis by suppressing SNRPG, which normally negatively regulates WT1 protein levels; loss of SNRPG permits WT1 accumulation and CDK14-driven metastatic phenotypes 6. SNRPG has been identified as a shared diagnostic biomarker for both Alzheimer's disease and metabolic syndrome, with involvement in glycolysis-metabolic and immune-regulatory pathways 789. Additionally, SNRPG appears relevant to acute pancreatitis-to-sepsis progression through oxidative phosphorylation pathway regulation 10. Its stable presence in extracellular vesicles makes it suitable as a reference gene for EV-associated RNA analysis 11.