RDH14 (retinol dehydrogenase 14) is an NADP-dependent enzyme that catalyzes the oxidation and reduction of retinoids, with high activity toward 9-cis, 11-cis, and all-trans-retinol but minimal activity toward 13-cis-retinol [UniProt function]. The protein localizes to multiple cellular compartments including the nucleoplasm, endoplasmic reticulum, and cytosol [GO annotations], with nucleoplasmic localization demonstrated in HEK293 cells 1. RDH14 is expressed in brain tissue 1 and plays a role in retinoid metabolism similar to other RDH family members 2. Biallelic mutations in RDH14 have been associated with autosomal recessive intellectual disability and cerebellar atrophy in a Pakistani family 1. The disease mechanism may involve disrupted retinoic acid signaling or altered chloride ion homeostasis through RDH14's binding interaction with PACC1/TMEM206, which is impaired by pathogenic mutations 1. Clinically, elevated RDH14 expression in second-trimester amniotic fluid has been identified as a potential biomarker for predicting spontaneous preterm birth, with expression changes correlating to oxidative stress and infection during pregnancy 3. These findings suggest RDH14 involvement in both normal retinoid metabolism and pregnancy-associated pathophysiology.