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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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RFPL4A
ret finger protein like 4A
Chromosome 19 Β· 19q13.42
NCBI Gene: 342931Ensembl: ENSG00000223638.5HGNC: HGNC:16449UniProt: A6NLU0
11PubMed Papers
12Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingubiquitin protein ligase activityregulation of gene expressioninnate immune responsecarcinoma of liver and intrahepatic biliary tractcolorectal cancerposterior cortical atrophycancer
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

ret finger protein like 4A

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜12
carcinoma of liver and intrahepatic biliary tractOpen Targets
0.02Suggestive
colorectal cancerOpen Targets
0.01Suggestive
posterior cortical atrophyOpen Targets
0.01Suggestive
cancerOpen Targets
0.01Suggestive
infectionOpen Targets
0.00Suggestive
breast cancerOpen Targets
0.00Suggestive
human herpesvirus 8 infectionOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
colorectal carcinomaOpen Targets
0.00Suggestive
cholangiocarcinomaOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
sarcomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
RFPL3Shared pathway100%RFPL2Shared pathway100%TRIM34Shared pathway100%TRIM49Shared pathway100%TRIM51Shared pathway100%TRIM4Shared pathway100%
Tissue Expression6 tissues
Liver
100%
Brain
10%
Bone Marrow
0%
Ovary
0%
Heart
0%
Lung
0%
Gene Interaction Network
Click a node to explore
RFPL4ARFPL3RFPL2TRIM34TRIM49TRIM51TRIM4
PROTEIN STRUCTURE
Preparing viewer…
PDB2FBE Β· 2.52 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.27LoF Tolerant
pLIβ“˜
0.11Tolerant
Observed/Expected LoF0.56 [0.27–1.27]
RankingsWhere RFPL4A stands among ~20K protein-coding genes
  • #16,881of 20,598
    Most Researched11
  • #13,387of 17,882
    Most Constrained (LOEUF)1.27
Genes detectedRFPL4A
Sources retrieved0 papers
Response timeβ€”