TRIM51 is a tripartite motif-containing protein with E3 ubiquitin ligase activity encoded by a core duplicon gene family member on chromosome 11. Structurally, TRIM51 is characterized by significant intrinsic disorder, with disordered regions facilitating protein-protein interactions and serving as substrates for posttranslational modifications 1. The protein localizes to the cytoplasm and participates in innate immune response and gene expression regulation pathways according to Gene Ontology annotations. Regarding disease relevance, TRIM51 has emerged as a potential genetic modifier in two complex diseases. A common variant (rs11604583) near the TRIM51 locus was associated with deep vein thrombosis (DVT) risk in large-scale genome-wide association studies, with polygenic risk scores incorporating this variant showing improved DVT prediction capacity 2. Additionally, TRIM51 variants showed association with clinical severity heterogeneity in hemoglobin E/beta-thalassemia patients, though statistical significance was lost after multiple testing correction 3. These findings suggest TRIM51 may modulate disease phenotypes through its ubiquitin ligase function, though its specific biological mechanisms in these disease contexts require further investigation.