1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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5PubMed Papers
4Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
ubiquitin protein ligase activityregulation of gene expressioninnate immune responsecytoplasmbrain compressionedemahypothyroidismThymoma
Based on limited published evidence, TRIM43B is a cytoplasmic E3 ubiquitin ligase involved in innate immune response and gene expression regulation. An associated long non-coding RNA (lnc-TRIM43B-1) was significantly downregulated in breast cancer tissues compared to non-cancerous samples, suggesting a potential role in tumor suppression 1. The lnc-TRIM43B-1 showed high diagnostic performance (AUC=0.82) for distinguishing breast cancer from normal tissues, indicating potential biomarker utility.
1
lnc-TRIM43B-1 is downregulated in breast cancer and may serve as a tissue marker with diagnostic potential (AUC=0.82)
PMID: 34175685⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
brain compressionOpen Targets
hypothyroidismOpen Targets
No pathogenic variants reported on ClinVar for this gene.