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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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TRIM64C
tripartite motif containing 64C
Chromosome 11 Β· 11p11.12
NCBI Gene: 646754Ensembl: ENSG00000214891.9HGNC: HGNC:37148UniProt: A6NLI5
6PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
ubiquitin protein ligase activityregulation of gene expressioninnate immune responsecytoplasmhypertensionanemia (phenotype)diabetes mellitushypertrophic cardiomyopathy
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

tripartite motif containing 64C

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
hypertensionOpen Targets
0.27Weak
anemia (phenotype)Open Targets
0.23Weak
diabetes mellitusOpen Targets
0.23Weak
hypertrophic cardiomyopathyOpen Targets
0.09Suggestive
neurodegenerative diseaseOpen Targets
0.07Suggestive
open-angle glaucomaOpen Targets
0.05Suggestive
venous thromboembolismOpen Targets
0.05Suggestive
colorectal adenocarcinomaOpen Targets
0.04Suggestive
physical activityOpen Targets
0.04Suggestive
cor pulmonaleOpen Targets
0.03Suggestive
kidney failureOpen Targets
0.03Suggestive
Alzheimer diseaseOpen Targets
0.02Suggestive
thyroid cancerOpen Targets
0.02Suggestive
preeclampsiaOpen Targets
0.02Suggestive
type 2 diabetes mellitusOpen Targets
0.02Suggestive
diabetic retinopathyOpen Targets
0.02Suggestive
cardiac arrhythmiaOpen Targets
0.02Suggestive
chronic obstructive pulmonary diseaseOpen Targets
0.02Suggestive
diabetic neuropathyOpen Targets
0.02Suggestive
heart failureOpen Targets
0.02Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
RFPL3Shared pathway100%RFPL2Shared pathway100%TRIM34Shared pathway100%TRIM49Shared pathway100%TRIM51Shared pathway100%TRIM4Shared pathway100%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
TRIM64CRFPL3RFPL2TRIM34TRIM49TRIM51TRIM4
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt A6NLI5
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.12LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.79 [0.56–1.12]
RankingsWhere TRIM64C stands among ~20K protein-coding genes
  • #18,242of 20,598
    Most Researched6
  • #11,597of 17,882
    Most Constrained (LOEUF)1.12
Genes detectedTRIM64C
Sources retrieved0 papers
Response timeβ€”