RGPD6 (RANBP2-like and GRIP domain-containing protein 6) is a nuclear-cytoplasmic trafficking protein implicated in neurodevelopmental and oncological disorders. The gene encodes a protein containing GRIP (glutamate receptor-interacting protein) domains, suggesting roles in signaling and protein-protein interactions. Primary function: RGPD6 contributes to nuclear-cytoplasmic trafficking and cellular signaling pathways 1. In cancer biology, circular RNA derived from RGPD6 (circRGPD6) regulates breast cancer stem cell maintenance and stemness through miR-26b/YAF2 axis modulation 2. Disease relevance: RGPD6 copy number variations are associated with multiple neurodevelopmental conditions. Duplications at 2q13 encompassing RGPD6 are linked to autism spectrum disorder, intellectual disability, and hepatic dysfunction 34. Deletions involving RGPD6 contribute to developmental abnormalities and increased phenotypic severity 1. Additionally, RGPD6 variants show association with schizophrenia susceptibility in East Asian populations 5, and RGPD6 expression correlates with hepatocellular carcinoma prognosis, with circRGPD6 serving as a therapeutic target for metastatic breast cancer 62. Clinical significance: RGPD6 emerges as a pleiotropic gene with relevance to psychiatric, neurodevelopmental, hepatic, and oncological diseases, offering potential targets for precision medicine interventions.