RGPD5 is a nuclear pore-associated protein containing RANBP2-like and GRIP domains that functions in nucleocytoplasmic transport. The protein exhibits SUMO transferase activity and participates in NLS-bearing protein import into the nucleus and nuclear export [GO Annotations]. RGPD5 is involved in nuclear-cytoplasm trafficking and signaling for tissue patterning and differentiation 1. Clinically, RGPD5 has relevance in developmental disorders. Heterozygous deletions of RGPD5 in chromosome 2 have been identified in patients with multiple congenital anomalies, where loss of this evolutionarily conserved gene contributed to phenotypic severity, particularly in cases with concurrent chr2 trisomies 1. In orofacial clefts with limb abnormalities, rare variants in RGPD5 were identified among developmentally relevant genes necessary for normal craniofacial and limb development in sub-Saharan African patients 2. In male fertility, RGPD5 expression is upregulated in Sertoli cells of patients with non-obstructive azoospermia, suggesting altered expression in male infertility-associated cytoskeletal dysfunction 3. Additionally, RGPD5 is targeted by miR-363-5p; low miRNA expression correlates with improved hepatocellular carcinoma prognosis, indicating potential involvement in cancer biology 4. These findings suggest RGPD5 functions in multiple biological contexts including development, reproduction, and oncology.