RGPD8 (RANBP2 like and GRIP domain containing 8) is a nucleoporin-related protein with homology to RanBP2/Nup358 1. The gene contains characteristic XFXFG repetitive sequence motifs typical of nuclear pore complex proteins 2, suggesting roles in nucleocytoplasmic transport consistent with its GO annotations for NLS-bearing protein import and nuclear export. RGPD8 can interact with Ran and transportin (karyopherin beta2) 1, supporting its proposed function as a docking site and cotransporter in nuclear import mechanisms. In testis tissue, the homologous nucleoporin BS-63 (RGPD8-related) localizes to nuclear pores in spermatids and can be phosphorylated by PKC and p34(cdc2) kinases 1, indicating regulatory post-translational modification. Disease relevance includes identification as a candidate biomarker in graft versus host disease patients 3 and a novel gene-disease association with liver cirrhosis identified through Mendelian randomization analysis, where decreased RGPD8 expression correlated with cirrhosis risk (Beta = -0.207) 4. Additionally, RGPD8 (as RGPD6, a related family member) was identified in a recurrent 2q13 microduplication associated with autism spectrum disorder, intellectual disability, and liver disease 5. These associations suggest RGPD8 involvement extends beyond nuclear transport to systemic health, particularly liver and neurological function, though mechanistic details remain to be elucidated.