Based on limited published evidence, RGPD3 is a nuclear protein containing RANBP2-like and GRIP domains with predicted roles in NLS-bearing protein import, nuclear export, and SUMO transferase activity. RGPD3 variants have been associated with craniofacial morphology, with specific SNPs linked to nasal length, ear length, and alar width in Han Chinese populations 1. Additionally, RGPD3 SNPs show evidence of positive selection in thyroid cancer susceptibility across East Asian and European populations 2, suggesting involvement in population-specific disease risk.