1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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2PubMed Papers
5Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
positive regulation of gene expressionDNA-binding transcription factor activity, RNA polymerase II-specificRNA polymerase II transcription regulatory region sequence-specific DNA bindingneuron developmentneurodegenerative diseaserespiratory system diseasechronic myelogenous leukemiaazoospermia
Based on limited published evidence, RHOXF2B is a transcription factor involved in reproductive processes. UniProt annotations indicate it modulates expression of target genes encoding proteins relevant to spermatogenesis. GO terms support its role as a DNA-binding transcription factor with RNA polymerase II-specific activity, involved in positive regulation of gene expression and chrX regulation. Recent epigenetic studies 1 demonstrate that RHOXF2B is a methylation-sensitive, germline-specific gene whose promoter can be reactivated through active DNA demethylation mechanisms, suggesting its importance in germline-specific gene regulation.
1
RHOXF2B is identified as a methylation-sensitive, germline-specific gene whose promoter can be reactivated through DNA demethylation processes involving TET-mediated oxidation of 5-methylcytosine
PMID: 37808741⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
neurodegenerative diseaseOpen Targets
respiratory system diseaseOpen Targets
chronic myelogenous leukemiaOpen Targets
No pathogenic variants reported on ClinVar for this gene.