RND2 (Rho family GTPase 2) is an atypical member of the Rho GTPase family that lacks GTPase activity and remains constitutively GTP-bound 1. RND2 is predominantly expressed in neurons and plays critical roles in neuronal development and morphology 12. The protein functions through multiple effector interactions to regulate cytoskeletal dynamics and neurite formation. RND2 binds to Rapostlin, which induces neurite branching by interacting with microtubules 2. Additionally, RND2 interacts with Pragmin to stimulate RhoA activity and inhibit neurite outgrowth, contrasting with other Rnd family members that typically antagonize RhoA signaling 3. Unlike Rnd1 and Rnd3, RND2 lacks the KERRA sequence required for lipid raft targeting and p190 RhoGAP activation 4. In cortical development, RND2 promotes radial migration through interaction with Bacurd2, influencing the multipolar-to-bipolar transition of migrating neurons 5. RND2 also functions as a transcriptional target of NEUROG2 during neurogenesis 6. In pathological contexts, RND2 is overexpressed in glioblastoma, where it attenuates apoptosis and autophagy by inhibiting p38 MAPK signaling, promoting tumor growth and correlating with poor patient survival 7.