RNF141 is a RING finger E3 ubiquitin ligase whose activity is modulated by S-nitrosylation, a post-translational modification mediated by nitric oxide 1. The gene is broadly expressed during vertebrate development, with zygotic expression strongly localized to the central nervous system, and knockdown studies suggest involvement in dorsoventral patterning and normal brain development 2. RNF141 expression is significantly altered in testicular tissue from infertile patients with nonobstructive azoospermia, where it represents a potential biomarker regulated by multiple miRNAs 3. In cancer biology, RNF141 functions as an oncogene by directly interacting with KRAS to promote its activation and membrane enrichment, enhancing colorectal cancer cell proliferation, migration, and invasion while suppressing apoptosis 4. RNF141 is upregulated in Barrett esophagus and esophageal adenocarcinoma progression 5, and may participate in cancer cachexia-associated fat loss through competing endogenous RNA networks involving miR-600 and miR-1224-3p 6. A rare missense variant in RNF141 co-segregated with carotid plaque in atherosclerosis-prone families 7. Overall, RNF141 represents a multifunctional E3 ligase with roles in developmental patterning, spermatogenesis, and cancer progression.