2 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
βGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
13PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITYβ Experimental GO Evidenceβ Swiss-Prot Reviewed
ubiquitin-protein transferase activityprotein bindingprotein autoubiquitinationnucleoplasmtriple-negative breast cancerbreast cancerneoplasmParkinson disease
Based on limited published evidence, RNF208 is an E3 ubiquitin ligase localized to the nucleoplasm with ubiquitin-protein transferase activity. RNF208 catalyzes protein ubiquitination and autoubiquitination through its ring finger domain 1. The protein is S-nitrosylated by nitric oxide, which modulates its E3 ligase activity 2. Functionally, RNF208 targets soluble vimentin for polyubiquitin-mediated proteasomal degradation in triple-negative breast cancer cells, suppressing metastasis. RNF208 expression is induced by 17Ξ²-estradiol in an estrogen receptor alpha-dependent manner, and low expression correlates with poor clinical outcomes in TNBC 1.
1
RNF208 is one of eight E3 ubiquitin ligases whose activities are modulated by S-nitrosylation
PMID: 241057922
RNF208 is an estrogen-inducible E3 ligase that polyubiquitinates soluble vimentin and suppresses metastasis in triple-negative breast cancer
PMID: 31862882β Limited data available β This gene has 2 indexed publications. Summary and analysis may be incomplete.
triple-negative breast cancerOpen Targets
breast cancerOpen Targets
Parkinson diseaseOpen Targets
Omenn syndromeOpen Targets
idiopathic hypereosinophilic syndromeOpen Targets
Hemolytic anemia due to red cell pyruvate kinase deficiencyOpen Targets
pyruvate kinase deficiency of red cellsOpen Targets
non-spherocytic hemolytic anemia due to hexokinase deficiencyOpen Targets
Hepatic veno-occlusive disease - immunodeficiencyOpen Targets
hepatic veno-occlusive disease-immunodeficiency syndromeOpen Targets
progressive familial intrahepatic cholestasis type 3Open Targets
dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edemaOpen Targets
hilar cholangiocarcinomaOpen Targets
Klatskin's tumorOpen Targets
severe combined immunodeficiency due to DCLRE1C deficiencyOpen Targets
Familial hemophagocytic lymphohistiocytosisOpen Targets
liver diseaseOpen Targets
LeishmaniasisOpen Targets
No pathogenic variants reported on ClinVar for this gene.