1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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9PubMed Papers
8Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingubiquitin protein ligase activityubiquitin-dependent protein catabolic processidentical protein bindingendocrine system diseaseatrial fibrillationinfectionavian influenza
RNF151 is a testis-specific RING finger protein with ubiquitin ligase activity. Based on limited published evidence, it contains a C3HC4-type RING finger domain and TRAF-type zinc finger domain, and is developmentally regulated during spermatogenesis 1. RNF151 localizes to the nucleus via its NLS and interacts physically with dysbindin 1. Given dysbindin's role in membrane biogenesis and fusion, RNF151 may be involved in acrosome formation of spermatids, though direct functional evidence remains limited.
1
RNF151 is testis-specific, developmentally regulated during spermatogenesis, contains functional RING and NLS domains, and physically interacts with dysbindin which is involved in acrosome formation
PMID: 17577571⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
endocrine system diseaseOpen Targets
atrial fibrillationOpen Targets
avian influenzaOpen Targets
cholangiocarcinomaOpen Targets
Hereditary breast cancerOpen Targets
hereditary breast carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.