Based on limited published evidence, RNF175 is a ring finger protein with ubiquitin ligase activity localized to endoplasmic reticulum and Golgi membranes, functioning in the ERAD pathway through protein binding. RNF175 was identified as a hub E3 ubiquitin ligase gene downregulated across multiple brain regions in Alzheimer's disease 1, though its specific role in AD pathology remains unreported. Additionally, RNF175 emerged as a candidate gene associated with electroconvulsive therapy response in treatment-resistant depression through DNA methylation analysis 2, though this pilot finding requires validation.