SCAF11 (SR-related CTD associated factor 11) is a splicing regulator that plays critical roles in pre-mRNA processing and spliceosome assembly. The protein functions as a nuclear splicing factor involved in RNA splicing via transesterification reactions and mRNA processing 1. SCAF11 can be co-sequestered to the cytoplasm along with other splicing regulators (SRSF5, TIAL1) in the context of TDP-43 pathology, leading to aberrant splicing of key transcripts including amyloid precursor protein (APP) 1. This cytoplasmic mislocalization contributes to splicing dysfunction across neurodegenerative diseases including ALS, FTLD, and Alzheimer's disease 1. Beyond neurodegeneration, SCAF11 has been implicated in diverse pathological contexts through expression profiling studies. It shows significant associations with height regulation in GWAS studies and exhibits altered expression in growth plate development 2. SCAF11 is also identified as a hub gene in endometriosis through co-expression network analysis, where it correlates with ubiquitin-mediated proteolysis pathways 3. Additionally, SCAF11 serves as a prognostic biomarker in multiple disease contexts including hepatocellular carcinoma 4, periodontitis 5, acute myocardial infarction 6, and type 1 diabetes 7, highlighting its broad clinical significance across diverse pathological conditions.