SRSF11 (serine and arginine rich splicing factor 11) functions as a pre-mRNA splicing regulator that controls alternative splicing of target genes through direct RNA binding 1. The protein undergoes post-translational modifications that regulate its activity, including succinylation at lysine 419 by KAT2A, which stabilizes SRSF11-spliceosome interactions and promotes specific exon inclusion events 2. SRSF11 also undergoes phosphorylation at serine 287 by PAK5, which protects it from ubiquitination-mediated degradation 1. The splicing factor regulates key cellular processes by controlling alternative splicing of genes involved in DNA repair (RAD52), cell adhesion (HSPA12A), and cellular senescence (Sirt1/P21) 213. METTL3-mediated m6A modifications can downregulate SRSF11 expression, linking RNA methylation to splicing control 4. Dysregulated SRSF11 expression is associated with multiple cancer types, including hepatocellular carcinoma, colorectal cancer, and oral cancer, where altered splicing promotes metastasis, radioresistance, and poor patient survival 215. Additionally, SRSF11 is regulated by exosomal miRNAs in vascular disease contexts, highlighting its broader pathophysiological significance 3.