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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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SCAI
suppressor of cancer cell invasion
Chromosome 9 · 9q33.3
NCBI Gene: 286205Ensembl: ENSG00000173611.19HGNC: HGNC:26709UniProt: Q8N9R8
43PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
nucleoplasmprotein bindingnegative regulation of cell migrationtranscription corepressor activitysmoking cessationsubstance-related disordersmoking initiationattention deficit hyperactivity disorder
✦AI Summary

Insufficient information to provide a gene function summary for SCAI (suppressor of cancer cell invasion). The provided PubMed abstracts exclusively concern clinical practice guidelines and cardiogenic shock classification systems published by the Society for Cardiovascular Angiography and Interventions (also abbreviated SCAI), a medical professional organization. These documents address the management of acute coronary syndromes, peripheral artery disease, pulmonary embolism, chr9 coronary disease, and cardiogenic shock in adult patients. None of the abstracts contain molecular or biological information relevant to the SCAI gene located on chromosome 9, its tumor suppressor function, mechanism of action through MRTFA/SRF transcriptional regulation, or its role in cell migration and Rho signaling pathways. To provide an accurate gene function summary grounded in peer-reviewed evidence, abstracts from studies investigating SCAI gene biology, protein interactions, transcriptional mechanisms, or cancer-related phenotypes would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
smoking cessationOpen Targets
0.42Moderate
substance-related disorderOpen Targets
0.38Weak
smoking initiationOpen Targets
0.37Weak
attention deficit hyperactivity disorderOpen Targets
0.32Weak
substance abuseOpen Targets
0.32Weak
Chronic painOpen Targets
0.31Weak
nerve plexus diseaseOpen Targets
0.29Weak
upper respiratory tract disorderOpen Targets
0.29Weak
Precordial painOpen Targets
0.26Weak
neurodegenerative diseaseOpen Targets
0.26Weak
PainOpen Targets
0.25Weak
opioid use disorderOpen Targets
0.22Weak
ovarian dysfunctionOpen Targets
0.22Weak
cannabis dependenceOpen Targets
0.21Weak
response to angiotensin-converting enzyme inhibitorOpen Targets
0.18Weak
frozen shoulderOpen Targets
0.15Weak
chronic obstructive pulmonary diseaseOpen Targets
0.10Suggestive
Abnormality of the skeletal systemOpen Targets
0.08Suggestive
Hallux valgusOpen Targets
0.07Suggestive
osteosarcomaOpen Targets
0.06Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
TP53BP1Protein interaction77%ARPINShared pathway33%GPBP1Shared pathway33%GPBP1L1Shared pathway33%PHF3Shared pathway33%POLR2J3Shared pathway25%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
51%
Ovary
44%
Lung
38%
Liver
27%
Heart
23%
Gene Interaction Network
Click a node to explore
SCAITP53BP1ARPINGPBP1GPBP1L1PHF3POLR2J3
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q8N9R8
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.70LoF Tolerant
pLIⓘ
0.45Tolerant
Observed/Expected LoF0.39 [0.23–0.70]
RankingsWhere SCAI stands among ~20K protein-coding genes
  • #9,782of 20,598
    Most Researched43
  • #5,295of 17,882
    Most Constrained (LOEUF)0.70
Genes detectedSCAI
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
PMID: 40013746
J Am Coll Cardiol · 2025
1.00
2
2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
PMID: 38743805
Circulation · 2024
0.90
3
2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
PMID: 40014670
Circulation · 2025
0.80
4
Criteria for Defining Stages of Cardiogenic Shock Severity.
PMID: 35835491
J Am Coll Cardiol · 2022
0.70
5
SCAI SHOCK Stage Classification Expert Consensus Update: A Review and Incorporation of Validation Studies: This statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association (AHA), European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC), International Society for Heart and Lung Transplantation (ISHLT), Society of Critical Care Medicine (SCCM), and Society of Thoracic Surgeons (STS) in December 2021.
PMID: 35115207
J Am Coll Cardiol · 2022
0.60