SCAND3 (SCAN domain containing 3) is a cytoplasmic protein involved in cell cycle regulation and epithelial cell proliferation 1. The gene has been identified as significantly mutated in sinonasal squamous cell carcinoma (SNSCC), occurring in 25% (3/12) of tumors analyzed, with mutations affecting cell cycle and epithelial cell proliferation pathways 1. SCAND3 shows concordant DNA methylation changes between assisted reproductive technology (ART) conception and leukemia/pre-leukemia, suggesting potential involvement in leukemia pathogenesis 2. A genetic variant upstream of SCAND3 (rs911178) is significantly associated with esophageal squamous cell carcinoma (ESCC) risk in Chinese populations, with the protective G allele showing decreased disease susceptibility 3. Additionally, SCAND3 has been identified as a genome-wide significant locus in female posttraumatic stress disorder (PTSD) etiology, revealing sex-specific genetic contributions to PTSD symptoms 4. At the molecular level, SCAND3 does not functionally complement the TcBuster transposon system, distinguishing it from other hAT-related proteins 5. These findings indicate SCAND3 plays roles in cancer development and psychiatric disease susceptibility, though mechanistic details require further investigation.