CCPG1 (cell cycle progression 1) functions as a reticulophagy receptor that mediates selective autophagic degradation of endoplasmic reticulum (ER) components. As a membrane-bound selective autophagy receptor, CCPG1 contains a LC3-interacting region (LIR) motif that enables interaction with autophagosomal LC3 and GABARAP proteins 1. CCPG1 operates as part of a redundant reticulophagy receptor system; deletion of CCPG1 alone partially blocks ER-phagy, while combined deletion with other receptors (TEX264 and FAM134B) nearly abolishes this process 1. The protein is involved in maintaining ER homeostasis under conditions including nutrient starvation and ER stress 23. CCPG1-mediated reticulophagy serves as part of cellular quality control mechanisms, with emerging evidence suggesting roles in antiviral defense against viral replication that depends on ER membranes 4. In glioblastoma cells, CCPG1 participates in ER stress-induced autophagy and autophagic cell death pathways 5. Additionally, CCPG1 shows differential degradation patterns under various cellular stresses, being spared during nutrient starvation but degraded during iron chelation 6. These functions indicate CCPG1's importance in ER homeostasis and potential therapeutic relevance in diseases involving ER dysfunction and abnormal autophagy.