GABARAPL2 (GABA type A receptor associated protein like 2) is a ubiquitin-like modifier protein that plays critical roles in both autophagy and intracellular membrane trafficking. The protein functions as an essential component of the autophagy machinery, particularly in the maturation stages of autophagosome formation, where it works alongside other LC3/GABARAP family members to facilitate cargo recognition and vesicle closure 1. GABARAPL2 is involved in selective autophagy processes, including mitophagy for mitochondrial quality control and ferritinophagy for iron homeostasis regulation 23. The protein contains LC3-interacting region (LIR) motifs that enable specific cargo receptor interactions and targeting to autophagosomes 4. Beyond autophagy, GABARAPL2 modulates intra-Golgi transport by coupling NSF ATPase activity with SNARE protein activation. Recent studies have identified GABARAPL2 as a binding partner for IRGQ in MHC class I quality control, where it directs misfolded MHC molecules toward lysosomal degradation, potentially contributing to tumor immune evasion mechanisms 5. The protein shows altered expression in various disease contexts, including diabetes mellitus and pulmonary fibrosis, where it regulates autophagy-dependent cellular processes 67. These diverse functions establish GABARAPL2 as a crucial regulator of cellular homeostasis through both autophagy-dependent and independent mechanisms.